Alex Yule, PhD

Recent Posts

Skin in the game: targeted dermatology drug development

Intro Dermatology, once a therapeutic category largely served by emollients, topical corticosteroids and small molecule immunosuppressants, is an increasing focus of targeted drug development. First...
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Extracellular vesicle (EV) therapeutics: good things in small packages

Extracellular vesicle (EV) therapeutics: good things in small packages Once considered simply as byproducts of cellular recycling and waste management, extracellular vesicles (EVs) have become the...
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The Rise and Rise of Antibody-Drug Conjugates

The path of the "magic bullet" Around the turn of the last century, Paul Ehrlich postulated that tailored and targeted drug delivery might be a means of treating disease1. Some eighty years later,...
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The race is on: after almost six decades, RSV vaccines near the finish line

The COVID-19 pandemic established that, when push comes to shove, successful vaccine development and deployment can be conducted at breakneck speed, even when largely untried and untested...
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Targeted Radiotherapy: The Comeback Kid of Cancer Treatment?

The notion that a systemically administered source of radiation can be usefully directed towards a tumor has been exploited since the 1940s, when radioiodine was introduced as a treatment for thyroid...
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Moving beyond cancer: CAR-T therapy takes on autoimmune disease

It’s not untypical for an emerging cancer treatments to be dubbed “revolutionary” or “game-changing”, but stepping beyond cliché, chimeric antigen receptor T-cell (“CAR-T”) therapy can rightly be...
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Monetizing the microbiome

Based on some neat guesstimating1, the number of bacteria in the gut roughly equals the number of cells in our bodies, so it’s no surprise that such a substantial (around 200g in a 70kg adult) and...
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