Axl/merTK target assessment for an AI-driven drug discovery company

Challenge: An AI-driven drug discovery company requested an expert third party assessment of the attractiveness and risks of a particular discovery strategy focused on a dual tyrosine kinase...
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Technical Feasibility Ranking of Gene Therapies for CNS Diseases

Challenge: A mid-sized pharmaceutical company was considering the option of expanding into developing gene therapies for CNS diseases. Alacrita was asked to help them evaluate and prioritize the...
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Identiying molecules for novel formulation technology

Challenge A company had developed a technology for overcoming solubility issues in drug formulations and was planning to develop a small number of 505 (b)(2) candidate molecules. The client had...
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Independent strategic review for clinical-stage biopharma developing a protein for multiple immune indications

Challenge A European clinical-stage biopharma company was developing a recombinant protein for multiple immune-driven indications and required support in shaping its future business strategy....
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Clinical landscape analysis for Tumor Infiltrating Lymphocytes

Challenge A European investor was refocusing its investment efforts and considering targeting the oncology cell therapy space. It had a particular interest in tumor infiltrating lymphocytes (TILs)...
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Strategic audit & turn-around strategy for global animal health company

Challenge A pharma investor client joined a European animal health company and asked Alacrita to conduct a strategic review, in the light of urgent business needs. The entire sector had been through...
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Inflammatory bowel disease primary market research & opportunity mapping

Challenge: A private venture-backed US biotech company was developing a biologic through late-stage drug discovery and wished to quantify the commercial opportunity for the product in treating anemia...
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Viral vector manufacturing landscape and bottlenecks

Challenge: A national biomedical research agency requested Alacrita’s support with (1) a technical assessment of the agency’s own internal capabilities in AAV manufacturing, (2) a global landscape of...
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Opportunity mapping for hemojuvelin antibody

Challenge: A US-based biotech company developing a novel biologic which impacts iron metabolism, wanted help deciding which disease and patient groups would make the best lead indication for...
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Indication prioritization for oligonucleotide-based therapeutics targeting age-related disorders

Challenge: A university spinout was developing oligonucleotide therapeutics to address age-related disorders. The company wanted to understand the most attractive lead indications in which to focus...
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Comparing clinical response rates for Tumor Infiltrating Lymphocytes against other therapeutic modalities

Challenge Alacrita supported the European arm of a major company creation investor as part of an ongoing workstream to evaluate the benefits of refocusing its investments into the tumour infiltrating...
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Development plan validation for novel small molecule for cancer

Challenge: For a university with an early stage novel inhibitor of the JAK2/STAT5 pathway intended to treat hematologic malignancies, Alacrita was asked to validate a development plan to support...
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